In October of 1964, Rev. John P. Lawler was appointed as Administrator of the Mission of Holy Cross prior to its formation as a parish. The parish territory was taken from St. Jude Cathedral in St. Petersburg and Sacred Heart in Pinellas Park. At that time there were 238 families registered in the new parish. Ten acres of land, located at 54th Avenue and 79th Street, North, St. Petersburg were purchased for parish use. On February l5, l965, the parish of Holy Cross in Northwest St. Petersburg was canonically erected by Archbishop Joseph Hurley of the Diocese of St. Augustine. The Diocese of St. Petersburg was established on June 17, 1968, under Bishop Charles McLaughlin. The first Mass was celebrated in Dixie Hollins High School’s auditorium on March 7, 1965. The new parish grew quickly with the formation of organizations, purchase of a school bus and beginning of CCD classes for grades 2 through 12, which were held in classrooms at Dixie Hollins High School. The parish met for six years at Dixie Hollins High School.

In January 1970, plans were approved for a new church. By coincidence on February 15, 1970, exactly five years after the establishment of the Parish, Bishop Charles McLaughlin officiated at the groundbreaking ceremony. On April 3, 1971, Rev. Michael Madden, Pastor, celebrated the first Mass in the newly built church. Bishop McLaughlin celebrated the dedication of the church on April 18, 1971.

Father Frank Mouch became the third pastor of Holy Cross in March of 1973 and continued developing the church with a strong focus on religious education. His leadership helped guide the parish through a turbulent time in the early 70’s. In March of 1974 Father Bernard Caverly became pastor and began construction of the parish office that autumn. Like his predecessor Father Caverly’s talents were recognized by the bishop and needed elsewhere in the diocese. In June 1976 Father Caverly became the rector of the Cathedral and Father Patrick Irwin became the fifth pastor of Holy Cross. For the next ten years, Holy Cross continued in growth and became a spiritual, active and dynamic parish. In order to serve more fully the increasing number of parishioners (2600 families in 1982), Bishop W. Thomas Larkin officiated at a groundbreaking for the new Parish Center on September 18, 1981, the feast day of Holy Cross parish, the Triumph of the Cross.

Bishop John C. Favalora appointed Robert L. Schaeufele as pastor of Holy Cross in June of 1991. His steadfast and spiritual leadership of ten years has brought the parish through the difficulties of a changing identity. These changes were due in part to the trimming of the parish boundaries in 1986 when the parish of St. Matthew was founded. Holy Cross has emerged as a smaller neighborhood parish which continues to be a vibrant and welcoming community.

In July of 2001, Bishop Robert N. Lynch appointed Rev. Thomas J. Anastasia as the seventh pastor of Holy Cross Church. Father Tom brings a youthful spirit to Holy Cross. Like Father Pat Irwin before him, this is his first pastorate. In his first six months, Father Anastasia has continued the work of collaboration with the building committee, the finance committee, and the parish staff. The renovation project is now moving forward with the possibility of construction on the first phase of the project in the summer of 2002. We now have a children’s chapel and a more conveniently located food pantry for the St. Vincent de Paul Society. The vision for the future continues to unfold but with the Holy Spirit as our guide and true active participation from the many gifted parishioners of Holy Cross, the parish is sure to grow and develop.

In June 2007, Bishop Robert N. Lynch appointed Rev. Paul Kochu as the eighth pastor of Holy Cross Catholic Church. Rev. Paul once served as an associate pastor years before under Robert L. Schaeufele. Rev. Paul Kochu continues to see new growth at Holy Cross. During the three years that Fr. Paul was at Holy Cross, the Parish Center was painted and new floors laid as well as new landscaping placed to make the property more appealing. During 2009, Fr. Paul began the process with Randolph Dolce, PGK to form a Knights of Columbus council at Holy Cross. The council was established and has been a supportive group to the church.

During the month of April 2010, Bishop Robert N. Lynch appointed Rev. John D’Antonio to serve as the ninth pastor of Holy Cross Catholic Church. Rev. John D’Antonio started his tenure as pastor on July 1, 2010 and was installed as the pastor by Rev. Bob Morris on September 25, 2010 at the 4:00pm mass. During 2010, the Columbiettes were also established to assist the Knights of Columbus as an auxilary organization in the Parish. Fr. John D’Antonio is the current and first chaplain for the Columbiettes.

During the month of April 2017, Bishop Gregory L. Parkes appointed Rev. Emery Longanga to Parochial Administrator of Holy Cross Catholic Church. Rev. Emery Longanga started his tenure as Parochial Administrator on July 1, 2017.